HOME THERAPY AREAS Relative vaccine effectiveness of cell- vs egg-based quadrivalent influenza vaccine against test-confirmed influenza over 3 seasons between 2017 and 2020 in the United States 2 May 2024 Vaccines Vaccines Influenza vaccine viruses grown in eggs may acquire egg-adaptive mutations that may decrease vaccine effectiveness. The present study compares cell- and egg-based quadrivalent influenza vaccines for preventing test-confirmed influenza over 3 US influenza seasons (2017–2020). Discover:· the current data on differences in vaccine effectiveness between cell- and egg-based influenza vaccines· the theoretical explanation of these differences View PDF