Home THERAPY AREAS Unmet needs in the treatment of SHPT 18 February 2022 Nephrology and Rare Diseases CKD-MBD and SHPT SHPT is a common complication of CKD that develops as the disease progresses and can result in vascular calcification and bone disease. Watch this short video on the complex pathogenesis of SHPT and how it is driven by 1,25(OH)2 vitamin D (calcitriol) deficiency, hypocalcemia, and hyperphosphatemia.